The NFL never sleeps, and neither does the betting value, and we are already at the end of September and NFL Week 4.
Last week was a rough one for most cappers and followers of my side’s column for BMR, as we went 0-3, after going 2-1 in NFL Week 2 and 3-0 in the NCAAF Week 2, which brings the column to 5-4.
Without letting the grass grow under our feet, let us get into the new week with a bet that stands out around a key number, and do not forget to keep an eye on the NFL live odds for all the up-to-date lines.
Jacksonville Jaguars vs. San Francisco 49ers (-3)
Sunday, September 28, 2025 – 4:05 PM EDT
This looks like a tight match-up as the Jacksonville Jaguars visit the West Coast for the San Francisco 49ers. Both are winning franchises in their current campaigns, with the Jags 2-1 and the 49ers unbeaten at 3-0.
You could argue that kind of scheduling has helped the 49ers, who this weekend had their third home game on a trot. This week, though, is more of a decisive test for both sides and an indicator of where their season expectations lie.
The opening spread at BetOnline was San Francisco -3, but strong support for the 49ers has pushed it to -4. The total opened at 45 and has climbed to 47 throughout the week. Jacksonville’s defense has been disciplined under first-year head coach Liam Coen, while Kyle Shanahan continues to find ways to win close games for the 49ers.
Check the live odds module for the latest numbers before kickoff, as late movement could create value on either side, and consider taking the under for this game.
New York Jets vs. Miami Dolphins (-3)
Monday, September 29, 2025 – 7:15 PM EDT
Monday Night Football features a crucial AFC East clash. Both franchises are 0-3 and chasing the opening win of their campaign. The Jets narrowly lost in Week 3 to a late field goal at Tampa Bay, while Miami has shown signs of life after losses to New England and Buffalo. Desperation will be high on Monday at the Hard Rock Stadium for Monday Night Football.
The opening total at Bookmaker was 44, and it has ticked slightly higher to 44.5, while the spread remains Dolphins -3. Given the strong defenses on both sides and their offensive limitations, there is value to be found in the total.
Remember to monitor the live odds module for the latest updates and consider taking the under for this game.
Carolina Panthers vs. New England Patriots (-5.5)
Sunday, September 28, 2025 – 1:00 PM EDT
This looks like a super get-right spot for the New England Patriots as they entertain the Carolina Panthers at home.
We know the Panthers are not the greatest team on the road, going 2-6 last year and 0-2 currently in their campaign. They have been unlucky with the schedule, so they are once again away in New England this week.
With head coach Mike Vrabel emphasizing ball security and discipline, this is a must-win game for the Patriots to stay on track with preseason expectations. Expect Mike Vrabel’s tenure as head coach to find its feet in Week 4.
The opening spread for New England was -4, and it has moved to -5.5, reflecting confidence in the home team. The moneyline opened at -205 and has strengthened to -245 at Heritage Sports, making a Patriots moneyline bet an attractive play.
Check the live odds module for the latest updates before placing your wager.
Place Your NFL Week 4 Bets Now
NFL Week 4 is filled with exciting betting opportunities, including key numbers in the Jaguars vs. 49ers, Jets vs. Dolphins, and Panthers vs. Patriots matchups.
Check our live odds module to lock in the best lines before they move, and start an account with one of our top sportsbooks today to get in on the action.
*The line and/or odds on picks in this article might have moved since the content was commissioned. For updated line movements, visit BMR’s free betting odds product.
