Saturday Night College Football Best Bets – Oct 11
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Jason Radowitz
- October 11, 2025
The excitement is building leading up to this Saturday’s college football.
There are a few matchups between opponents that are both in the Top-25. However, there are also some games between a Top-25 team and other conference teams that can totally pull off an upset.
Make sure you don’t forget about the Indiana-Oregon game.
Indiana is rising to the top of the rankings in the Big Ten and in all of college football. Indiana will likely be a top-four team if the Hoosiers can find a way against an undefeated Oregon team. I’ve got a pick in that game along with two other college football picks.
Betting The Big Ten: My Picks
I’ve decided on my favorite three bets of the day. Oddly enough, all three games are in the Big Ten.
While I’m not sure if Ohio State is the best team in the nation, it’s clear that they’re one of the deepest teams in the country. If Indiana can destroy them, so can Ohio State.
Speaking of Indiana, the Hoosiers are playing Oregon. Head coach of Indiana, Curt Cignetti, has won everywhere he’s been. But can he find a way to beat a top-3 team in the country on the road? My data suggets he can.
Finally, the Michigan-USC game should be a thriller. If USC is able to get by against Michigan, the Trojans will find themselves ranked again. At home, USC’s offense is trustworthy.
Ohio State Buckeyes vs. Illinois Fighting Illini (+14.5)
The Ohio State Buckeyes will look to stay at the top of the college football rankings with a road game against Illinois.
Illinois already has one loss on the schedule against Indiana, and it was a bad one. That said, the Fighting Illini have earned back-to-back wins over USC and Purdue since.
Still, Illinois’ secondary was exposed in an earlier 63-10 loss to Indiana.
In addition, the Fighting Illini have allowed at least 32 points in each of their last three games, including their last two wins. Ohio State’s offense is certainly able to score 30+ points.
Meanwhile, the Buckeyes’ defense has limited all five teams played to no more than nine points this season. The Buckeyes are in line for a blowout win.
Expert Pick: Ohio State -14.5 (-107) at BetOnline
Indiana Hoosiers vs. Oregon Ducks (-7)
Above, I already spoke highly of Indiana. The Hoosiers took care of business against that same Illinois team, 63-10. They won’t put up a score like that against Oregon.
But Indiana should still be competitive.
Fernando Mendoza has escapability in the pocket and will take on an Oregon defense that doesn’t have a pass rush up to Oregon standards right now. Meanwhile, the Ducks most recently defeated Penn State on the road in overtime.
The fact that Penn State lost to UCLA the following week leaves me a bit concerned about Oregon. The Ducks even allowed 14 points to Northwestern and 13 to Montana State this year.
Indiana will score enough points to stick around.
Expert Pick: Indiana +7 (-110) at BetOnline
Michigan Wolverines vs. USC Trojans (-2.5)
Both squads are 4-1 heading into this game.
Michigan has won three straight since its 24-13 loss to Oklahoma earlier this season. Meanwhile, USC just lost on the road to Illinois, 34-32 a couple of weeks ago.
USC’s defense up front needs to play better. The run defense and pass rush have been below standard. However, Michigan’s offense, led by freshman Bryce Underwood, isn’t up to standards, either.
Underwood hasn’t been a great passer, and he doesn’t have top-tier receivers that he can rely on. Jayden Maiava of USC has thrown for nearly 600 more yards than Underwood in the same number of games.
I’ll trust USC’s offense more in this one.
Expert Pick: USC -2.5 (-115) at BetOnline
Bet CFB On Your New Sportsbook Account
I’m betting on three huge Big Ten games for this Saturday’s college football.
If you’d like to tail, consider joining a new sportsbook to take advantage of all of the bets mentioned above. These sportsbooks always have some kind of promotional or bonus offer that can be applied to these bets as well.
Have an exciting weekend and good luck on all your bets!
*The line and/or odds on picks in this article might have moved since the content was commissioned. For updated line movements, visit BMR’s free betting odds product.
