Friday Night College Football: Best Bets for November 21

Swinging Johnson
November 21, 2025

This week, Florida State takes to the highway and invades Carter-Finley Stadium, home of the NC State Wolfpack, in a clash of ACC rivals. After reviewing the NCAAF odds at all of the best offshore sportsbooks, we found opportunities with the side and a team prop in our Friday night football bets.

Our college football bets on Friday night also take into consideration the AI predictions made by BMR’s proprietary algorithm, which shows Florida State winning and covering the number.

Best Bets for Florida State vs. NC State

Both of these teams check in with identical 5-5 straight-up records, but the Seminoles are also 5-5 against the number, while the Wolfpack sits at 4-6 ATS.

The last time out, Florida State trounced Virginia Tech and covered as two-touchdown home chalk in a convincing 34-14 romp. Conversely, NC State was manhandled by Miami, 41-7, and never even sniffed a cover as 14½ point road underdogs.

After researching this matchup and shopping the odds at the best online sportsbooks, tonight’s NCAAF picks are focused on laying the lumber with the home favorite.

Friday Odds (NC State +4½)

The NCAAF odds for this clash of ACC foes show the Seminoles of Florida State opening up as five-point road favorites, but that number has drifted south at virtually all of the major online sportsbooks to where it now stands at FSU -4½.

Those interested in the total will be interested to hear that this game opened at 62 and has dropped to as low as 60 at Bookmaker, while Bovada appears to be the lone sportsbook holding to the original total.

Friday Picks (NC State +4½)

BMR’s algorithm model predicts a 35-27 Florida State victory, but these teams appear to be going in opposite directions based on last week’s results. Yes, the Wolfpack played a much stronger team in Miami than FSU did in Virginia Tech.

However, NC State was lackluster from start to finish, and if they haven’t awoken from their slumber, the high-flying FSU offense will steamroll them and not look back. Consider that the Seminoles rank:

8th in total yards (487.5)
10th in rushing yards (227.7)
40th in passing yards (259.8)
17th in points scored (36.4 PPG)

Now consider that NC State’s defense is ranked:

127th in total yards allowed (440.4)
55th against the run (140.5)
136th against the pass (300)
120th in points allowed (31.6 PPG)

Those who tell you that FSU has not fared well against the Wolfpack are right. NC State has defeated FSU in five of the last six meetings. But like anything else, if you torture the numbers long enough, they’ll confess to almost anything. In other words, what they neglect to tell you is that these teams have not met since 2022, which means that the stat is useless.

Lastly, North Carolina State has lost three of its last four games and has given up more than 35 points in all four of those contests.

Back FSU in this one!

Expert Pick: Florida State -4.5 (-110) at Bookmaker

Florida State’s Tommy Castellanos Over 235 Passing Yards (-114)

Florida State will be looking to throw early and often when senior quarterback Tommy Castellanos settles in under center. Consider that NC State’s secondary has been cooked big time over their last four games, allowing:

367 passing yards to Miami
408 to Georgia Tech
423 to Pittsburgh
342 to Notre Dame

After checking out the player props for this game, it looks like Bovada is giving us the biggest bang for our betting buck on this prop. Castellanos will have all day to survey the field and pick out his targets against this anemic NC State defense, so go high in this one.

Expert Pick: Tommy Castellanos Over 235 Passing Yards (-114) at Bovada

Make Your Friday Night Football Bets Now

Getting in the game with an opinion that makes you cash is what it’s all about. The only way to do that is to open an account at one or more of the most trustworthy, reliable, and reputable sportsbooks in the industry, like the several online sportsbooks featured at Bookmakers Review.

Remember, the lines and odds don’t stay stagnant. They move, so why not review our Friday night football bets on Florida State and over 235 passing yards for Tommy Castellanos and strike while the iron is hot? Lock in on a line at top offshore sportsbooks like Bovada and Bookmaker, and you’ll never have to worry that you missed out on value.

*The line and/or odds on picks in this article might have moved since the content was commissioned. For updated line movements, visit BMR’s free betting odds product.