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It sure is quiet here when everyone is sleeping 😴😴😴😴

BMR Genie

BMR Genie

Joined
Jun 16, 2016
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50,009
I came across this story last week. A good read.


A complete version:

"In the late 20th century, an Italian man named Silvano began experiencing persistent insomnia. At first, it seemed manageable. He had difficulty falling asleep and woke frequently during the night. Doctors initially suspected stress.
But the condition progressed.
Over time, sleep became nearly impossible. His body remained awake through the night, and restorative sleep never came. As weeks passed, he developed severe anxiety, hallucinations, confusion, memory impairment, and loss of coordination. His heart rate remained elevated. His body temperature fluctuated. Basic autonomic functions became unstable.
Doctors eventually identified the cause: Fatal Familial Insomnia (FFI), an extremely rare inherited prion disease.
FFI primarily affects the thalamus, a region of the brain essential for regulating sleep-wake cycles. As the disease progresses, the brain gradually loses its ability to generate normal sleep patterns. Standard sedatives and medications are ineffective because the underlying sleep-regulating structures are degenerating.
Over months, neurological decline continues, affecting speech, movement, and autonomic control. There is currently no cure.
This case helped reshape scientific understanding of sleep. It demonstrated that sleep is not a passive shutdown state but an active, highly regulated brain function dependent on specific neural structures. When those structures are compromised, normal sleep cannot occur.
Fatal Familial Insomnia remains one of the rare conditions in which progressive neurological deterioration includes the near-total loss of natural sleep.
Source: Lugaresi, E., et al. (1986). Fatal familial insomnia and dysautonomia with selective degeneration of thalamic nuclei. New England Journal of Medicine; Italian Neurological Institute."
 
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