Patriots vs. Buccaneers NFL Week 10 Showdown: Odds, Preview, and Best Bets

Matt Ryan
November 7, 2025

The eyes of NFL fans will be glued to Raymond James Stadium this Sunday, November 9, 2025, as the red-hot New England Patriots travel to face the Tampa Bay Buccaneers. Kickoff is set for CBS’s afternoon slate in a high-stakes Week 10 matchup with major playoff implications and compelling betting opportunities.

Game Breakdown: Patriots Riding High, Buccaneers Eager With Rest

The Patriots march into Tampa riding a remarkable six-game winning streak, coming off a razor-thin 24-23 victory over the Atlanta Falcons. Quarterback Tommy DeVito has piloted New England’s offense to an impressive average of 238.3 passing yards per game. The ground game has been nearly as impactful, with the Pats chewing up 112.3 yards per contest behind a dynamic backfield.

On the flip side, Tampa Bay sports a stout defense, surrendering only 92.6 yards on the ground per game while allowing 228.8 passing yards on average. Quarterback Baker Mayfield, steering the Bucs’ ship, leads an outfit averaging 224.9 passing yards per game. But Mike Evans’ absence (IR) leaves a glaring hole in the receiving corps—something Bill Belichick’s underrated pass defense (only 223.6 yards allowed per game) will surely look to exploit.

Key Matchups: Trenches Matter, Injuries Loom Large

Both sides pride themselves on winning the battle in the trenches. The Patriots’ pass protection has outshined the Buccaneers’ pass rush so far, perhaps tilting the balance in giving DeVito enough time to test a Bucs secondary that yields plenty of air yards. Conversely, Tampa’s offense—though efficient—meets its toughest challenge yet in the Patriots’ defensive front, which allows a paltry 75.4 rushing yards per game.

New England may have to sweat out the status of star corner Christian Gonzalez (questionable), a would-be vital piece against Mayfield. Tampa Bay’s biggest blow is the prolonged absence of Evans, long the primary chain-mover for their offense.

Betting Trends and Odds:

Spread: Buccaneers -2.5 ( BetOnline)
Total/Over-Under: 48 to 48.5 points
Moneyline: Patriots +124 | Buccaneers -148

The Patriots have dominated the road, sitting undefeated both straight up (4-0) and against the spread. Tampa Bay is 2-1 at home and comes off a dominant win in New Orleans before their bye, potentially lining them up as the fresher side.

Prediction: Who Gets the Edge?

This game has all the makings of another classic, much like the 19-17 nail-biter when these teams last met in 2021. The Patriots’ momentum is real, backed by a balanced offensive attack and a defense that refuses to break. Tampa Bay gets the betting market’s nod as a home favorite, but the absence of Evans and the Patriots’ impressive ATS road streak can’t be ignored.

Final Score Prediction from BMR Odds:

Patriots 27, Buccaneers 24

Best Bets:

Patriots +2.5 (-104 to -110): Ride New England’s road dominance in a game that could go either way.
Patriots Moneyline (+124): Value play for those believing in the outright upset.
Over 48 (-118): Both Rushing/Passing offenses can exploit matchup edges for points.

Bottom Line

Betting-wise, back the Patriots with the points and take a strong look at the Over. Keep a close eye on injury reports and check for the best lines at BetOnline, Bovada, and BetOnline.

The Pats are hot, the Bucs are rested, and NFL fans have a Sunday afternoon treat lined up. However you play it, expect fireworks at Raymond James Stadium.