We are officially at the mid-point of the regular NFL season, and we are tracking all the live NFL odds week 10 lines as they move.
Last week was difficult as top picks—the Green Bay Packers, Indianapolis Colts, and Detroit Lions—all lost.
Let’s try some better luck with these other football predictions.
NFL Odds Week 10 At-a-Glance
This guide provides an overview of this week’s NFL odds, analyzing team performance, injury updates, and scoring trends to assist bettors in forecasting potential line movements for profit.
We launch with the eagerly anticipated clash between the divisional rivals of the Buffalo Bills and the Miami Dolphins.
Buffalo Bills vs. Miami Dolphins (+9)
Sunday, November 09, 2025 – 01:00 PM EDT
Last week, the Bills did us a favor by beating the Kansas City Chiefs at their Highmark Stadium. This week, they visit their struggling AFC East rivals, the Miami Dolphins.
The Bills’ look-ahead line was –9 and remains unchanged, with a slight increase at some sites. The total started at 50 and is still about the same, though a few sportsbooks have made minor downward adjustments.
Bookmaker offers a total of 49.5, which makes me lean toward betting the over since there are no weather concerns.
That same operator lists the Dolphins at +10. If these odds remain stable or improve, Miami would be considered my preference, as the Bills tend to do just enough to win when they are heavy favorites.
Atlanta Falcons vs. Indianapolis Colts (-5.5)
Sunday, November 09, 2025 – 09:30 AM EDT
This week’s matchup in Berlin, Germany, features the Indianapolis Colts designated as the home team against the Atlanta Falcons.
This matchup is on neutral ground, and I question whether the Falcons’ +6.5 opening line was too high, considering their robust performance in New England with a +5.5 handicap.
The look ahead before the Colts lost on Sunday to the Steelers was Colts –7 on the current season form, but if that number was factoring in home advantage, it was wrong.
With the line at +5.5, the Atlanta Falcons remain the preferred pick after the Colts faced challenges against the Steelers in Week 9.
New York Giants vs. Chicago Bears (-3.5)
Sunday, November 09, 2025 – 01:00 PM EDT
Chicago’s weather will play a key role in this week’s bets and odds as the New York Giants visit on Sunday.
Although earlier forecasts were stable, meteorologists now predict a sharp temperature drop below freezing on Sunday, along with icy winds.
That will lower the total points from the current 48.5, which increased after last week’s high-scoring Bears and Giants games allowed sportsbooks to raise the line from 47.5.
This game suggests an over 48.5 total; check Chicago’s weather, as a warmer Sunday could make this a strong play if the line holds.
Get Your NFL Week 10 Bets On!
Weather will play a key role in two games; monitor the Chicago forecast and check the NFL odds for overs if the Sunday cold snap eases.
Some severe weather in Miami could also help reduce scoring and narrow the handicap against the Bills. That said, make sure to track the NFL odds Week 10 on our live page to spot advantageous line or total changes.
*The line and/or odds on picks in this article might have moved since the content was commissioned. For updated line movements, visit BMR’s free betting odds product.
