Top Picks for NFL Wild Card Weekend: 49ers vs. Cowboys

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Jimmy Garoppolo #10 of the San Francisco 49ers. Lachlan Cunningham/Getty Images/AFP

We finally are at the NFL Wild Card Weekend! There’s one game in particular I’m keeping a close eye on: San Francisco 49ers vs. Dallas Cowboys. This should be a good clash, so read below for my NFL Prediction

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San Francisco 49ers vs. Dallas Cowboys

Sunday, January 16, 2022 – 04:30 PM EDT at the AT&T Stadium

San Francisco

The 49ers are coming off of a 27-24 victory in overtime against the Los Angeles Rams. 

In their win, the 49ers had 314 passing yards and 135 rushing yards, with 6.7 yards per play. San Francisco held their opponent to 265 total yards - 201 passing yards & 64 rushing yards - and 4.1 yards per play. 


The Cowboys are coming off of a grand 51-26 win over the Philadelphia Eagles.

In their high scoring victory, Dallas had 7.8 yards per play, 304 passing yards and 171 rushing yards. Philadelphia finished the game with 4.5 yards per play, 166 passing yards and 149 rushing yards. 


The current NFL Odds are: San Francisco +3 (-108) and Dallas -3 (112). 

It’s obvious why the Cowboys are the favorite going into this Wild Card Weekend. They have one of the top offenses in the playoffs, and they are coming off of a high scoring win against the Eagles. 

Their overall squad appears to be unstoppable; the Cowboys defense are great at getting turnovers. 

But let’s not forget about the 49ers who have an underrated defense that will definitely come into play. They will give the Cowboys O the pressure they need to contain them and keep up with the points.

And yes, we will need to point out Jimmy G’s hurt thumb, but he also showed what he can do with that hurt thumb in their victory in week 18. 

I expect big plays on both ends, but the 49ers will come through with the upset. I will side with the dog and take the 49ers. 

NFL Pick: San Francisco 49ers +3 (-108) at BetOnline (Visit our BetOnline Review

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San Francisco 49ers +3 (-108)
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