Serie A, La Liga, and Carabao Cup Betting Picks for Wednesday

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Real Madrid's Brazilian forward Vinicius Junior. (Photo by JAVIER SORIANO / AFP)

Serie A, La Liga, and Carabao Cup soccer odds are now available as we are back with our favorite European expert advice and soccer betting picks. Read on for this Wednesday’s most favorable betting picks, soccer analysis, and free betting advice.

SSC Napoli vs. Spezia Calcio

Wednesday, December 22, 2021 – 02:45 PM EST at Diego Armando Maradona Stadium

Routine Home Victory Despite Injury Crisis

This Wednesday, Napoli will gladly welcome low-tiered Spezia to Diego Armando Maradona Stadium with unlimited confidence in their favor.

Defeating AC Milan amid a severe injury crisis has reinvigorated Napoli's title chase ahead of the halfway point in Serie A, and their visitors will struggle to equal Napoli's on-pitch abilities, with or without the players missed in Milan at the weekend.

Napoli's reach to claim their first Scudetto win since the Diego Maradona era took a slight downtrend in recent weeks, but a hard-fought battle in Milan solidified a genuine Serie A contender for defending titleholders Inter Milan.

Four points shy of Inter's 1st place position, Napoli's reign under Luciano Spalletti has maintained its glory despite a crippling injury crisis. And another 3-point success against Spezia could draw Spalletti and company even closer to Serie A's top spot.

Final Thoughts | Serie A Betting Picks

Spezia has lost six consecutive away fixtures, a trend that will be difficult to break against the title chasers.

In addition to their woeful away outings, Spezia left empty-handed in five of their previous seven fixtures in all competitions, including an embarrassing loss to Serie B side US Lecce.

Several key players absent in Napoli is undoubtedly a concern, but this is Spezia – a significantly weaker team that Napoli can exploit.

The available Serie A odds aren't providing much leeway, so I'll take my chances on wagering with Napoli to win both halves of play.

Napoli vs. Spezia Score Prediction: Napoli 3 – Spezia 0

Soccer Pick: Napoli to Win Both Halves (+145) [2.45] [1u wager returns 1.45u of profit] at Everygame (visit our Everygame Review)

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Napoli to Win Both Halves (+145) [2.45]
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Athletic Club vs. Real Madrid CF

Wednesday, December 22, 2021 - 03:30 PM EST at San Mamés Stadium

The Real Madrid We Know and Love

Unlike their fellow Spanish giants Barcelona, Real Madrid has long overcome a worrisome form and sits 5 points clear on top of the Spanish La Liga.

Madrid will make the trip to Bilbao, who occupies the 9th position, having collected 24 points from their initial 18 fixtures of the 2021/22 season.

Athletic won't be bullied on home turf; only Sevilla (2) and Real Madrid (1) have lost fewer La Liga meetings than Marcelino's squad this term. However, before Sunday's meeting with Real Betis, Bilbao rode an 8-game winless run in domestic competition.

A shocking 0-0 bore draw against Cádiz CF saw Real Madrid's 10-game win streak ended on Sunday, though a significant number of players were missing due to positive COVID-19 tests.

Final Thoughts | La Liga Betting Picks

Los Blancos are in excellent form and have remained undefeated since October 3, their only 2021/22 campaign loss. They've advanced into the Champions League knockout stage, and we have no doubt Ancelotti's men will be eyeing their 14th win of the season when traveling to San Mamés. January delivers a busy schedule for Real Madrid, and they won't want to drop points after the Cádiz CF mishap.

The COVID-19 absentees shouldn't remove Real Madrid's capabilities for a second game running, and given the available La Liga odds, I'd like to pounce on such value whilst it's available.

Athletic Club vs. Real Madrid Score Prediction: Athletic Club 1 – Real Madrid 2

Soccer Pick: Real Madrid to Win (+125) [2.25] [1u wager returns 1.25u] at Everygame

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Real Madrid to Win (+125) [2.25]
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Tottenham Hotspur FC vs. West Ham United FC

Wednesday, December 22, 2021 - 02:45 PM EST at Tottenham Hotspur Stadium

Bitter Rivals Clash in a London Derby

Trophy droughts for both Tottenham and West Ham can be easily reversed by lifting the EFL Cup, but the pressure will be on when West Ham takes the short trip from West to North London for a classic rivalry matchup.

Fresh from a near-two-week absence due to an in-squad coronavirus outbreak, Tottenham held title-chasers Liverpool to a 2-2 draw this past weekend. Fresh legs couldn't ultimately prevail, but Antonio Conte's squad proved that a well-rested team doesn't necessarily lose focus.

A 14-year trophy drought for Spurs doesn't quite contend with West Ham's 31-year drought, but domestic and European results for the Hammers this year have given hope towards the club's future.

Whilst Tottenham is well-rested, West Ham has also had an extra week to prepare following the cancellation of their EPL meeting with Norwich.

Defeating Manchester United at Old Trafford and Manchester City in October will feel like West Ham already deserves the EFL trophy, but this should boost the confidence of David Moyes's team when another challenging fixture lies in wait.

Final Thoughts | Carabao Cup Betting Picks

I expect a tightly fought contest where both managers will fight to progress into the Carabao Cup semi-finals, making the halftime/draw betting value a tempting position to be in.

Tottenham Hotspur vs. West Ham United Score Prediction: Tottenham Hotspur 1 – West Ham United 1

Soccer Pick: First Half - Draw (+105) [2.05] [1u wager returns 1.05u of profit] at Everygame

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First Half - Draw (+105) [2.05]
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*The line and/or odds on picks in this article might have moved since the content was commissioned. For updated line movements, visit BMR’s free betting odds product.