Teams on Upset Alert in NFL Week 16

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Saquon Barkley #26 of the New York Giants. Rey Del Rio/Getty Images/AFP

There are some interesting matchups for Week 16 in the NFL. Here are some potential upset options for Week 16. Let’s take a look at the NFL odds and decide which way to lean at top sportsbooks.

Indianapolis Colts vs. Arizona Cardinals 

Saturday, December 25, 2021 – 08:15 PM EST at State Farm Stadium

This is kind of an obvious underdog spot. The Colts are currently 8-6 on the season and coming off a huge win against the Patriots. Now they’ll take the road to take on the Arizona Cardinals. The Cardinals just lost badly to the Detroit Lions and looked completely out of sync on both ends of the field. Arizona has now lost three of their last five games with the only wins coming against Seattle and Chicago.

Both of those games were double-digit wins, but certainly not blowouts. Meanwhile, the Colts have won four of their last five games and have just one loss to the Buccaneers in that time span, which finished as a one-score game.

The Colts have scored more than four touchdowns per game this season while allowing just over three touchdowns per game. The offense is starting to peak, especially with Jonathan Taylor at running back. Taylor has rushed for 1518 yards with 17 touchdowns on 270 carries. Quarterback Carson Wentz is finally starting to feel comfortable and healthy for the Colts.

He’s thrown 23 touchdowns and just six interceptions on the year. Basically, the Colts started the season slowly because of a bunch of injuries. Things are starting to develop in Indianapolis and they’ll get to go up against a struggling Arizona team, on the road, as underdogs. For our NFL picks, why not take the Colts in this spot, at +102?

NFL Pick: Colts (+102) with BetOnline (visit our BetOnline Review)

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Colts (+102)
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New York Giants vs. Philadelphia Eagles 

Sunday, December 26, 2021 - 01:00 PM EST at Lincoln Financial Field

I just gave out a +102 underdog. That’s not really fair so I’ll give out a massive underdog here. The Giants are around +360 on the money line and already defeated the Eagles once this season. So why can’t they do it again?

In rivalries, stats don’t always add up. If the Giants elect to start Jake Fromm at quarterback, you just never know what will happen with the Giants offense. Maybe Fromm is a gem in the making. Maybe he can turn the corner for the Giants if he gets an opportunity.

I wouldn’t take the Giants here without knowing Fromm is starting. But if he is, I’d be confident to put a little change on the Giants money line at +360. The Giants have so many weapons on this team and it's kind of embarrassing that they can’t figure out a way to use it.

From Saquon Barkley to Kenny Golladay, the Giants have an offense that should be capable of more. Fromm has played in so many big games throughout his career in college and led a Georgia Bulldogs team through so much. For our best bets, I just want to see Fromm get his chance. And if he gets his chance, I think the Giants play well behind him and help keep the game tight throughout.

NFL Pick: Giants (+360) with BetOnline

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Giants (+360)
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*The line and/or odds on picks in this article might have moved since the content was commissioned. For updated line movements, visit BMR’s free betting odds product.