Rams vs. Giants NFL Week 6 Picks and Odds Breakdown

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Aaron Donald #99 of the Los Angeles Rams. Steph Chambers/Getty Images/AFP

With the Giants all dinged up this week, can the Rams put New York away quickly, on the road, and go 5-1 on the season? Let’s see the NFL odds.

Los Angeles Rams vs. New York Giants

Sunday, October 17, 2021 – 1:00 PM EDT at MetLife Stadium

The New York Giants have fallen to 1-4 on the season. They’ve lost most of their key contributors for multiple games and have plenty of questions on the offensive and defensive end that have yet to be answered. We can start with Daniel Jones, the starting quarterback who has a concussion and might be unable to play Sunday.

Then we’ll go to the starting running back, Saquon Barkley, who is injured and is currently in a walking boot and crushes. After that, the wide receiver, Kenny Golladay injured his knee and Sterling Sheppard and Darius Slayton have already been out with hamstring injuries.

It looks as though starting left tackle Andrew Thomas will be available and play on Sunday but everyone else is a mystery. So we’ll cap this game with Mike Glennon at quarterback and Devonte Booker at running back, We’ll assume Kadarius Toney will be the lead receiver along with John Ross III and CJ Board.

This is not a team you’ll want to bet on offensively. The defense, on the other hand, has been very bad, allowing 418.8 yards per game with 27.8 points allowed per game. The offense couldn’t even score 21 points consistently with Jones, Barkley, Golladay, Slayton, and Sheppard. Without those guys, it’s going to be hard against a 4-1 Rams team.

The Rams are averaging 415.4 yards per game and 28.2 points and while the defense has struggled as of late, this could be Los Angeles’ first game of consistent defense. The rushing defense has been spectacular, holding teams to 117.2 yards per game and the pass rush is still effective, despite a secondary that is getting beat badly.

The Giants' offensive line won’t be able to hold off Aaron Donald and the Rams pass rush all game and will force plenty of mistakes out of Glennon, who threw two interceptions last week, including a pick-six. Meanwhile, the Rams have had more than a week to prepare for this game, after winning on Thursday Night over the Seahawks. With the Giants banged up, the Rams are going to be extra healthy.


It’s steep at -10,5, but I like the Rams to win by multiple touchdowns. The Giants would be able to stick around in games with a healthy unit but the fact of the matter is they’re not healthy. Last week, Glennon had some great moments and some terrible moments.

He found Ross III down the field for a touchdown and also threw a pick-six along with another interception. I wouldn’t trust the Giants as a 14-point underdog right now. The Rams are stacked offensively and should dominate the Giants front-seven along with the secondary that is playing well below standard for this Giants team.

For your NFL picks, take the Rams -10.5 (115) in this matchup and watch the Rams win by multiple touchdowns.

NFL Pick: Rams -10.5 (115) with BetOnline (visit our BetOnline Review)

Rams -10.5 (115)
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