Panthers vs. Bills Free NFL Week 15 Picks and Odds Breakdown

Josh Allen #17 of the Buffalo Bills. Andy Lyons/Getty Images/AFP.

Following a loss to the Atlanta Falcons at home, the Carolina Panthers (5-8) head north to Buffalo to take on the Bills. Meanwhile, the Bills (7-6) also enter Week 15 off a loss after losing to Tom Brady in overtime. 

Which team will get back on track? Below, we’ll take a look at the early NFL odds and best sportsbook to bet with. 

Carolina Panthers vs. Buffalo Bills

Sunday, December 19, 2021 – 01:00 PM EST at Highmark Stadium

The Panthers entered Week 14 as 2.5-point favorites and are now the team getting the points this week. As for the Bills, they were 3.5-point underdogs last week but are the heavy favorite for this matchup for our NFL picks. According to Heritage Sports, Buffalo is a 10.5-point favorite over Carolina with the over/under at 43.5.

The Matchup

The Panthers lost a third straight contest, falling 29-21 to NFC South rival, the Falcons. Both quarterbacks, Cam Newton, and P.J. Walker were intercepted and one was returned for a 66-yard touchdown. Newton even found himself benched following the pick-six. He finished the day completing 16-23 passes for 178 yards, and zero touchdowns. Also, after letting Carolina run all over them on Halloween, the Falcons held them to just 91 rushing yards. 

As for the Bills, they came close to an underdog victory but fell short in overtime, losing 33-27––their second straight loss on the season. Buffalo played until the final whistle, outscoring Tampa 24-3 in the second half, but the GOAT, Tom Brady, tossed a 58-yard TD to seal the deal.

Josh Allen completed just 35 of 54 passes for 305 yards and 2 touchdowns. He also threw one interception. Buffalo hasn’t been the team we saw earlier the year, kicking off the season 4-0. Instead, they’re a 3-5 team entering this matchup. 

Since rejoining the league in the midst of the season, Newton has completed just 58.7 percent of his passes for 467 yards, 3 touchdowns, and 3 interceptions. While Allen is completing 65.8 percent of his passes for 3,524 yards, 28 touchdowns, and 11 interceptions.

Defensively, the Panthers are allowing 21.7 points and 293 yards per game compared to Buffalo, who is allowing an average of 17.6 points and 283.9 yards.


It’s Week 15 and the Panthers are still dealing with a QB crisis. Not to mention the fact that their key weapon, Christian McCaffrey, is done for the season again, so their only major run threat is Newton himself.

The Bills are obviously the much better team and if they can hold the run and force turnovers the way the Falcons were able to, then their high-scoring offense can take it from. Carolina won’t keep up this time. 

NFL Pick: Buffalo Bills -10.5 (-108) at Heritage Sports (visit our Heritage Sports Review)

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Buffalo Bills -10.5 (-108)
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*The line and/or odds on picks in this article might have moved since the content was commissioned. For updated line movements, visit BMR’s free betting odds product.