The 1:00 kickoff window will have major implications in the AFC South, with the top three teams in the division all in action, including a matchup of the first and second-place teams.
A half-game separates the first-place Tennessee Titans and second-place Indianapolis Colts, meaning the winner of their showdown in Nashville takes over the top spot in the division.
Meanwhile, the surprising Jacksonville Jaguars will face an even bigger surprise when the 5-1 New York Giants come to town.
Indianapolis Colts vs. Tennessee Titans
Sunday, October 23, 2022 – 01:00 PM EDT at Nissan Stadium
Everything seems to be coming up Titans in this game. Tennessee is in first place, has won three straight games, will get the home-field advantage, and is coming off of a bye last weekend.
The week off helped the Titans get healthy. Coach Mike Vrabel is hopeful that linebacker Bud Dupree, safety Amani Hooker and right guard Nate Davis, who have all missed time, will be able to play on Sunday.
Davis will help bolster a line that struggled in the last game, allowing quarterback Ryan Tannehill to get sacked five times.
Receiver Racey McMath and corner Elijah Molden, both eligible to be activated from injured reserve this week, have both already been ruled out for the game.
The Colts have won two games in a row, including a divisional win over the Jaguars at home on Sunday, but things haven’t been all rosy for Indianapolis. The Colts have a -18 point differential on the year and posted their first win over a divisional opponent in four games this season. Plus, Indy scored its first touchdown since Week 4 and topped 20 points for the first time in eight games.
The Colts were down their top two running backs, with Jonathan Taylor and Nyheim Hines both out, and Deon Jackson hurt his quad in Sunday’s game, making Indianapolis even thinner at the position. Return man Keke Coutee also suffered a concussion in the game.
On defense, injured safety Julian Blackmon was able to suit up for last Sunday’s game, his first time on the active roster since hurting his ankle in Week 3. He never made it to the field, however. Coach Frank Reich said the Colts kept him out to give him “another week” to recover.
Colts vs. Titans: Our Betting Pick
Matt Ryan was able to light up Jacksonville last week, but he’ll struggle against a Titans pass rush that should include Dupree. Look for Tennessee to grind out a win.
NFL Pick: Titans -3 (+102) at BetOnline
New York Giants vs. Jacksonville Jaguars
Sunday, October 23, 2022 - 01:00 PM EDT at TIAA Bank Field
New York Giants
The Giants have completely turned things around, running out to a 5-1 record, one more than last season’s win total over 17 games. New York has won three straight games, coming back from a 10-point deficit to beat Baltimore last weekend, the third time this season the Giants have rallied from being down double digits.
New York is led by a group of surprising rookies, including first-year coach Brian Daboll, who has changed the attitude in the Giants locker room. Nine rookie players saw the field in the last game, with four starting. Edge rusher Kayvon Thibodeaux had a key strip sack last week, and Daniel Bellinger’s three touchdowns are second on the team to only Saquon Barkley.
The Jaguars are in third place in the division at 2-4, but Jacksonville is the only AFC South team with a positive point differential, at plus 24. The Jags have lost three straight, including last weekend at Indianapolis.
Jacksonville is coming off of losing a late lead against the Colts. Wide receiver Jamal Agnew went down in the game with a strained knee, and he is day-to-day, according to coach Doug Pederson.
The Jaguars have improved by leaps and bounds this year, following a dismal 2021 season, but their playoff push will take a hit against a Giants team that is rolling. It’s tough to go against New York, especially getting points.
NFL Pick: Giants +3 (-104) at BetOnline
*The line and/or odds on picks in this article might have moved since the content was commissioned. For updated line movements, visit BMR’s free betting odds product.