Must-See Games in the 2022 NFL Season

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Cooper Kupp #10 of the Los Angeles Rams is tackled by Taron Johnson #24 of the Buffalo Bills. (Photo by Bryan M. Bennett / GETTY IMAGES NORTH AMERICA / Getty Images via AFP)

The NFL schedule was recently released, and fans can now start planning their weekends. We know when the biggest games of the season are happening and have the schedule for the primetime games of the year.  

So, what are the biggest games of the upcoming NFL season? Here are some games for bettors and casual fans alike. These games will be must-see television, so mark your calendars and be ready to watch some of the best football of the upcoming season.  

Buffalo Bills vs. Los Angeles Rams

Thursday, September 08, 2022 – 08:20 PM EDT at SoFi Stadium

This is as good of an opening game as you could ask for. In fact, it could easily be the final matchup of the season as well. The Bills are +425 favorites to win the AFC, and the Rams are at +450 to win the NFC once again.  

This will also be a reunion for Von Miller. Miller was traded to Los Angeles in the middle of last season, and he signed with Buffalo as a free agent. It is hard to call this a revenge game after Miller played half a season and won a Super Bowl ring, but he is still playing the team he left in his first game with his new franchise.  

The Bills improved the roster with a strong free agency class, and they are set to win the AFC East easily. The Rams have tougher competition, but they could easily win the NFC West and be one of the best teams in the conference. Either way, one of these top teams will end the season without a win.  


Tampa Bay Buccaneers vs. Kansas City Chiefs

Sunday, October 02, 2022 - 07:20 PM EDT Raymond James Stadium

This will be one of the best Sunday Night Football games of the year. If Tom Brady retires after this year, this will likely be the last matchup between him and Patrick Mahomes, the face of the NFL. This could also be a preview of the Super Bowl. 

It will at least be a rematch of Super Bowl LV, where Brady dismantled the Chiefs while Mahomes struggled to play behind an injured offensive line. These teams are familiar with each other, and the matchup will be elite.  

The Chiefs are without Tyreek Hill, but they added multiple quality receivers through the draft and free agency. After four weeks, the offense should have developed enough chemistry to be competitive against the stout Bucs defense.  


Philadelphia Eagles vs. St. Louis Cardinals

Sunday, October 09, 2022 - 03:25 PM EDT at University of Phoenix Stadium

This may not be a matchup between Super Bowl favorites, but it is still going to be must-see television for a few reasons. For starters, these are two of the three best dual-threat quarterbacks in the NFL. Both teams will be running dynamic offenses with mobile quarterbacks.  

Without DeAndre Hopkins, the Cardinals will have to rely more on Kyler Murray’s dynamic abilities, so expect him to make electric plays with his feet.  

The Eagles are a sneaky team to win the NFC East, and the Cardinals are a sneaky team to win the NFC West. Both offenses will be fun to watch, and we will likely see plenty of highlights. This may not be a bettor’s dream, but it will at least be an exciting matchup of two mobile quarterbacks.  


Denver Broncos vs. Seattle Seahawks

Monday, September 12, 2022 - 08:15 PM EDT at Lumen Field

I don’t like having two must-see games in the first week, but this is the best revenge game of the season unless Baker Mayfield becomes a starter against the Browns later in the year. Wilson helped bring a Super Bowl to Seattle, but the energy has been off for years. Now, his first game as a Denver Bronco will be against his former team in their stadium.  

To add intrigue, this is also Drew Lock’s first game as a starter for Seattle, assuming he wins the job. This is a unique situation where two teams traded quarterbacks and play each other in the first game of the next year.  

The Broncos will be heavily favored. If the Seahawks somehow upset the Broncos, the narratives about the Broncos being overrated will write themselves. Either way, it will be interesting to see how Seahawks fans react to Wilson coming out of the visitor’s locker room.