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49ers vs. Eagles NFL Week 2 Best Bets and Odds Analysis

49ers vs. Eagles NFL Week 2 Best Bets and Odds Analysis
Jimmy Garoppolo #10 of the San Francisco 49ers. Gregory Shamus/Getty Images/AFP

On Sunday, September 19th the San Francisco 49ers kick off Week 2 with a road trip to the City of Brotherly Love to take on the Philadelphia Eagles. Last week, the Niners were able to pull off a 41-33 win against the Detroit Lions while the Eagles absolutely smacked the Atlanta Falcons 32-6. Below, we’ll take a look at the early NFL odds and best sportsbooks to bet with.

San Francisco 49ers vs. Philadelphia Eagles

Sunday, September 19, 2021 – 1:00 PM EDT at Lincoln Financial Field

The Niners barely covered the 7.5 spread, almost letting Detroit pull off a back door cover. And of course, the Eagles absolutely crushed the 3-point spread as underdogs. According to BetOnline (visit our BetOnline Review) the 49ers enter this week as a 3 ½ -point favorite, leaving the Eagles as the underdogs for the second week in a row. The over/under comes in at 50 1/2.

The Matchup

It wasn’t their best performance, but the San Francisco 49ers managed to hold off a Detroit Lions. While doing so, the Niners took a blow to their secondary and lost cornerback Jason Verrett to a season-ending ACL tear. Their starting running back Raheem Mostert also went down with a knee injury and will be out for the remainder of the season after opting to undergo season-ending surgery.

Backup running backs JaMycal Hasty and rookie Eli Mitchell took over the workload for Mostert and each scored touchdowns to save the day.  Now, the Bay Area team will be tasked with facing the Philadelphia Eagles who managed a blowout road win over the Falcons. First-year Falcons head coach Arthur Smith blamed himself for not preparing his team for Week 1.

The good news is, Kyle Shanahan has prepared his team and the 49ers are a much better team than the lackluster Falcons squad we saw against the Eagles. Not to mention that the 49ers will have the Eagles preparing to take on not one, but two different quarterback styles after Shanahan opted to use both Jimmy Garoppolo and Trey Lance last week.

On the Eagles front, young QB Jalen Hurts threw for 264 yards and 3 touchdowns on 27-for-35 passing in his first-ever Week 1 start. He also added 62 rushing yards on 7 carries. Meanwhile, Heisman winner DeVonta Smith proved his worth as he led the receiving corps with 71 yards on 6 receptions from 8 targets. Philly’s defense was able to keep Atlanta in check and limited former MVP quarterback Matt Ryan to just 164 passing yards and zero touchdowns and starting running back Mike Davis to only 49 yards on 15 carries. 


We will find out for sure this week if the Philadelphia Eagles are actually a good team under new head coach Nick Sirianni and second-year quarterback Jalen Hurts, or did they just beat up on a really bad Falcons team? Real football starts now.

NFL PickSan Francisco 49ers -3 ½  (-108) with BetOnline (visit our BetOnline Review)

*The line and/or odds on picks in this article might have moved since the content was commissioned. For updated line movements, visit BMR’s free betting odds product.