White Sox vs. Cubs MLB Odds, Preview and Pick

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In search of a winning baseball pick for Hump Day, we’re headed to the Windy City for the all-Chicago showdown between the White Sox and Cubs at Wrigley Field. 

Chicago White Sox vs. Chicago Cubs 

Wednesday, May 04, 2022 – 08:10 PM EDT at Wrigley Field

Mother Nature didn’t stop Tuesday’s series opener between the White Sox and Cubs, though life did get in the way. The Cubs were forced to make a last-minute change in their pitching plans due to a death in Drew Smyly’s family, and the White Sox took advantage of it in a 3-1 victory to open the set with a much-needed win. 

Tony La Russa’s crew is looking for the mini-sweep on Wednesday, and according to the numbers at the best online betting sites, the White Sox will get it when they send Lucas Giolito (0-1, 2.57) out to face Kyle Hendricks (1-2, 5.47) of the Cubs. The White Sox are -141 at BetOnline (visit our BetOnline Review), and as is the norm for games at Wrigley, the total has not been released.  

Pale Hose Currently in 1-4 O/U Spurt 

Tuesday’s triumph allowed the White Sox to keep pace with Minnesota and Cleveland ahead of them in the AL Central. Tim Anderson swatted his fourth home run of the campaign, and the White Sox took advantage of an early Cubs error on what was a rather miserable Chicago evening on the weather side of things. 

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One look at how things have gone for Giolito so far, and it’s easier to understand why the White Sox have been slumping early. He made just one start before missing a couple of weeks with an abdominal strain, and the White Sox have yet to win any of his three starts, the most recent of which came last Friday against the Angels who earned a 5-1 win as +135 underdogs at top-rated sportsbooks

Giolito missed facing the Cubs each of the last two seasons, so Wednesday will be the first time he’s seen them since 2019. It has been a struggle for the big Californian when he has gone up against the Cubs, Giolito going 1-3 in four career starts with a 5.47 ERA. He is 1-1 with an 8.10 ERA in two appearances at Wrigley Field.  

Cubbies in Drought With Only 6 Runs Last 5 Games

David Ross would really love to see some of his young hitters bust loose. Tuesday’s setback marked the fourth time in five games the Cubs scored just one run, all of those contests going into the loss column, and they’ve managed to cross the plate just 16 times in the last eight contests. 

Should Hendricks follow the script of his ’22 season to date, then lay everything you got on the MLB odds on the Cubs. He’s pitched to a 1.62 ERA in his three starts at Wrigley, with the Cubs winning each time, and gone 0-2 with a 13.50 ERA in his two starts away from home. Hendricks is coming off one of those losses last Friday in Milwaukee (4.1 IP, 6 ER, 3 HR). 

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Then again, the White Sox have been knocking Hendricks around pretty good the past few seasons regardless of where the games are played. The Cubs have dropped each of his last four starts against the White Sox, Hendricks fashioning a 6.75 ERA and serving up six gopher balls in the 20 innings of work. 

Another Chilly Evening in Chi Town

The good news is the rain and most of the wind is gone from the Chicago forecast; the bad news is it still won’t be ideal baseball conditions. According to the weatherman, the thermometer will be in the low-40s at first pitch with a 12 mph northerly breeze (in from left). 

With a name that sounds more like he should be a NASCAR driver, Junior Valentine will be calling balls and strikes for Bill Miller’s umpire crew. Now in his third season, the 34-year-old Tennessee native is 1-4 O/U at the dish this year, all four of his ‘under’ winners coming with the MLB betting odds at 8½ runs or less, which the total will certainly be on Wednesday. 

The scoreboard target should be in the 6½ to 7 range once it is released. I’m going to run with the home underdogs despite their recent offensive woes. Cubs win, 4-3. 

MLB Pick: Cubs (+130) at BetOnline 

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Cubs (+130)
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*The line and/or odds on picks in this article might have moved since the content was commissioned. For updated line movements, visit BMR’s free betting odds product.