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Odds courtesy of BetOnline Sports (Read full review here)
| US Open - WTA Quarters | | Womens US Open - Quarter 3 Winner |
| | | | | |
| 11:00 AM | 260301 | Naomi Osaka | | +105 | |
| 260305 | Elena Rybakina | | +550 | | |
| 260302 | Elina Svitolina | | +550 | | |
| 260303 | Simona Halep | | +700 | | |
| 260323 | Sloane Stephens | | +700 | | |
| 260304 | Angelique Kerber | | +800 | | |
| 260307 | Daria Kasatkina | | +1800 | | |
| 260318 | Leylah Fernandez | | +2500 | | |
| 260312 | Anhelina Kalinina | | +15000 | | |
| US Open - WTA Quarters | | Womens US Open - Quarter 4 Winner |
| | | | | |
| 11:00 AM | 260401 | Aryna Sabalenka | | +210 | |
| 260402 | Barbora Krejcikova | | +225 | | |
| 260403 | Garbine Muguruza | | +600 | | |
| 260405 | Victoria Azarenka | | +650 | | |
| 260406 | Ons Jabeur | | +700 | | |
| 260407 | Danielle Collins | | +850 | | |
| 260404 | Elise Mertens | | +1000 | | |
| 260433 | Kamilla Rakhimova | | +6600 | | |
| Friday, Sep 03, 2021 | | | | | |
| US Open - ATP Quarters | | Mens US Open - Quarter 3 Winner |
| | | | | |
| 11:00 AM | 250301 | Stefanos Tsitsipas | | +105 | |
| 250302 | Andrey Rublev | | +225 | | |
| 250313 | Carlos Alcaraz | | +900 | | |
| 250305 | Roberto Bautista-Agut | | +900 | | |
| 250303 | Felix Auger-Aliassime | | +1000 | | |
| 250317 | Frances Tiafoe | | +1600 | | |
| 250332 | Peter Gojowczyk | | +2000 | | |
| 250329 | Henri Laaksonen | | +2500 | | |
| US Open - ATP Quarters | | Mens US Open - Quarter 4 Winner |
| | | | | |
| 11:00 AM | 250401 | Daniil Medvedev | | -450 | |
| 250403 | Diego Schwartzman | | +400 | | |
| 250406 | Daniel Evans | | +900 | | |
| 250409 | Alexei Popyrin | | +1600 | | |
| 250427 | Alex Molcan | | +5000 | | |
| 250429 | Botic Van De Zandschulp | | +6600 | | |
| 250419 | Pablo Andujar | | +8000 | | |
| 250413 | Facundo Bagnis | | +10000 | | |
